Seminario - Milano Bicocca

Seminars in Biostatistics and Epidemiology

Methods for mediation and interaction:

application to genetic variants on 15q25.1,smoking and lung cancer



Speaker: Tyler VanderWeele, Harvard University, Boston, MA,
Time: 12:30-13:30, October 1, 2012
Location: University of Milano-Bicocca, U7 - Second Floor Aula Tesi (A.DeLillo),
Host: Rino Bellocco
Methods developed for causal mediation analysis with a dichotomous outcome, applicable to case-control studies via prevalence weighting will be presented. These methods generalize traditional approaches to mediation in the social sciences by allowing for interactions and non-linear models. Methods for sensitivity analysis for unmeasured confounding and measurement error in the context of mediated effects will be described. The methodology is used to resolve a question concerning direct and indirect effects in genetic epidemiology.